Clinical Trials

Current Studies

E7181 A Multicenter, Retrospective Series Using a New Injection Capable Electrosurgical Knife for Endoscopic Submucosal Dissection (ESD)

Current Studies

Integrated Cancer Repository for Cancer Research (iCaRe2)- Subproject: Pancreatic Cancer Collaborative Registry

OBJECTIVES: Develop Integrated Biomedical Computing Tools (IBCT) for the better understanding and treatment of pancreatic cancer by using the power of computer and informatics sciences. Continue development of the Pancreatic Cancer Collaborative Registry (PCCR) infrastructure to act as a...

Current Studies

Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions (CLIMB)

Primary Outcome Measures: Accuracy of PCL diagnosis [Time Frame: 48 months] Diagnostic accuracy of confocal laser endomicroscopy and/or cyst fluid molecular markers and/or composite clinical and imaging features for the diagnosis of mucinous PCLs, PCLs with malignant potential, specific PCL types,...

Current Studies

A Novel Retraction Device for Endoscopic Submucosal Dissection (ESD): A Multicenter Retrospective Study

Specific Study Aims: Study Aim 1: The primary aim of this study was to determine the technical success of ESD using the retraction device by determining completeness of the resection (¬en-bloc vs incomplete). Study Aim 2: We aim to determine the safety of the device with regards to perforation and...

Current Studies

Multi-center Prospective Evaluation of the Clinical Utility of Endoscopic Submucosal Dissection (ESD) in the Western Population

Primary An Excision of the targeted lesion in a single specimen Secondary Rate of R0 resection Time Frame 3-4 hours when all vertical and horizontal margins are negative Rate of R1 resection Time Frame 3-4 hours complete resection with no grossly visible lesion defined by...

Current Studies

Multicenter Prospective Evaluation of the Efficacy of a Self-Assembling Matrix Forming Gel to Prevent Stricture Formation in High-Risk Patients

Primary Objective/Aim/Goal/Hypothesis Aim. The primary aim is to evaluate the efficacy of the SAP gel in the prevention of stricture formation following endoscopic resection in high-risk patients

Current Studies

Evaluation of the Clinical Outcomes of Peroral Endoscopic Myotomy for the Treatment of Esophageal Dysmotility in Patients on Chronic Opioids

Primary Aim Retrospective analysis of clinical outcomes of POEM for the treatment of symptomatic esophageal dysmotility in patients on chronic opioids. Secondary Aim Factors associated with clinical response to POEM in patients on chronic opioids.

Current Studies

A Multicenter Randomized Controlled Trial of Surveillance vs. Endoscopic Therapy for Barretts Esophagus with Low-grade Dysplasia

3.1 Primary Objective: To compare the effectiveness of two approaches for the management of Barrett s esophagus (BE) and low-grade dysplasia (LGD), endoscopic surveillance and endoscopic eradication therapy (EET), using an accepted clinical endpoint of neoplastic progression [high-grade dysplasia...

Current Studies

Outcomes of Submucosal Tunneling Endoscopic Resection for Subepithelial Tumors in the Upper Gastrointestinal Tract: Experience from the United States

To investigate the safety and efficacy of STER and EFTR for treatment of SELs in the upper GI tract.

Current Studies

Evaluation of Outcomes of Advanced Endoscopic Resection and Endoscopic Trans-Mural Drainage Techniques: A Multicenter Study