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How medications and targeted treatments work together

Last Modified: August 26, 2026

Family Medicine, Diseases & Disorders

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This post was written by Dr. Andrius Giedraitis, Pain Management at Parkview Bryan Hospital.

Pain is one of the most common reasons patients seek medical care, yet treating it effectively requires more than a one-size-fits-all approach. Modern pain management has evolved into a thoughtful, multimodal strategy that combines medications, physical restoration and targeted interventions. While medications remain an important part of care, they are only one component of a broader philosophy focused on improving function and quality of life.

The role of medications in pain management

For many patients, medications are the starting point. They can help reduce pain, improve comfort and create an opportunity to re-engage in daily activities. When used appropriately, medications can be highly effective, particularly in the early stages of treatment or during pain flare-ups.

Several classes of medications are commonly used, each designed to address different types of pain:

Anti-inflammatory medications (NSAIDs): Nonsteroidal anti-inflammatory drugs, such as ibuprofen and naproxen, are often used to treat inflammation-related pain. Conditions like arthritis, muscle strain and acute injuries typically respond well to these medications. By reducing inflammation, they address one of the underlying drivers of pain. However, long-term use must be approached carefully, as these medications can impact gastrointestinal, kidney and cardiovascular health.

Neuropathic pain medications: Medications such as gabapentin and duloxetine are used to treat nerve-related pain. Unlike traditional pain relievers, these medications stabilize overactive nerve signals. They are particularly helpful for patients experiencing burning, tingling or shooting pain, such as in cases of sciatica or peripheral neuropathy.

Muscle relaxants: Muscle relaxants are often prescribed when muscle spasms contribute to pain, particularly in the neck or back. By reducing muscle tension, they can help break the cycle of pain and tightness. These medications are generally used for short durations due to their sedating effects.

Topical agents: Topical treatments, including lidocaine patches and anti-inflammatory gels, provide localized relief. Because they are applied directly to the area of discomfort, they minimize systemic side effects while still offering meaningful symptom control for certain conditions.

Opioids: Opioid medications may be appropriate in select cases, particularly for severe or acute pain, or for cancer-related pain. However, their use requires careful consideration.

Over time, patients may develop tolerance, requiring higher doses to achieve the same effect. This can increase the risk of dependence and side effects without necessarily improving function or long-term outcomes. For this reason, opioids are used cautiously and typically as part of a broader, closely monitored treatment plan.

Understanding the limits of medication

While medications can be helpful, they often function as a blanket approach to pain relief. They circulate throughout the body, affecting multiple systems, even when pain originates from a very specific source.

As pain becomes chronic, this approach can become less effective. Increasing medication doses does not always lead to better results and may introduce additional risks. Equally important, pain relief alone is not the ultimate goal of treatment.

Shifting the focus to function

In modern pain management, success is measured not only by reduced pain, but by improved function. This includes a patient’s ability to move more comfortably, participate in daily activities and return to meaningful aspects of life.

Questions that guide treatment often include:

  • Can you walk farther or move more freely?
  • Has your sleep improved?
  • Are you able to participate in work, hobbies, or family activities?

Medications can support these goals, but they are most effective when used as part of a larger plan that prioritizes functional progress.

The role of interventional procedures

Interventional pain procedures offer a more targeted approach to treatment. Rather than affecting the entire body, these therapies target the source of pain.

Examples include:

  • Nerve blocks, which temporarily interrupt pain signals from specific nerves.
  • Joint injections, which deliver anti-inflammatory medication directly to the affected area.
  • Radiofrequency ablation (RFA), which uses heat to disrupt pain signals from targeted nerves for longer-lasting relief.

This precision allows for more effective pain control without the widespread effects associated with systemic medications.

A balanced, patient-centered approach

The most effective pain management plans integrate multiple strategies. Medications can provide initial relief and create an opportunity for progress. Interventional procedures can address pain at its source. Physical therapy and activity help restore strength and mobility. Together, these approaches reduce the need for escalating medication doses and support more sustainable, long-term outcomes.

Ultimately, the goal of pain management is not simply to reduce discomfort, but to help patients regain function, independence and quality of life. By combining thoughtful medication use with targeted interventions, we can move beyond temporary relief and toward meaningful, lasting improvement.

Find care

At Parkview Bryan Hospital's Pain Management Clinic in Ohio, our team offers personalized and balanced care with no referral necessary. To learn more or schedule an appointment with one of our providers, call 419-633-7343.

At PPG—Pain Management in Indiana, appointments are by referral only. If you suspect you need to see a pain management specialist, contact your primary care physician.