Genetics

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Genetics Center

Using the latest techniques and state-of-the-art equipment, the Parkview Genetic Center’s staff helps you and your family discover chromosomal change or damage that is at the root of many health conditions. Ask us how genetic testing can empower you with information.

​Genetics Center

The Parkview Genetics Center is qualified to test blood, bone marrow and other types of human tissue sample to detect genetic abnormalities and solve health mysteries. As one of Indiana’s two cytogenetic facilities, the center can be a tremendous resource for you and your family.

Cutting-edge diagnosis

Using the latest techniques and state-of-the-art equipment, the center’s staff can help you and your family discover chromosomal change or damage that could be at the root of your health conditions.

This facility tests for conditions associated with:

Cancer:

  • Acute Myelocytic Leukemias (AML)

  • Chronic Myelocytic Leukemias (CML)

  • Myelodsyplastic Syndromes (MDS)

  • Myeloproliferative Disorders (MPD)

  • Acute Lymphocytic Leukemia (ALL)

  • Chronic Lymphocytic Leukemia (CLL)

  • Lymphomas

  • Multiple Myeloma

  • Anemia

  • Breast Cancer (HER-2/neu testing)

Behavioral issues:

  • ADD

  • ADHD

  • Asperger Syndrome

  • Autism

  • Chemical dependency

  • Depression/mood disorders

  • Fetal alcohol syndrome (FAS)

  • Prader Willi Syndrome

  • Sotos Syndrome

  • Developmental issues

  • Prenatal and neonatal disorders

  • Fertility concerns

Developmental Issues:

  • Cystic Fibrosis

  • DiGeorge Syndrome

  • Down Syndrome

  • Failure to thrive

  • Kleinfelters Syndrome

  • Lack of normal growth/development

  • Marfans

  • Metabolic disorders

  • Miller Dieker Syndrome

  • Noonans Syndrome

  • Physical birth defects

  • Smith Magenis Syndrome

  • Turners Syndrome

  • Williams Syndrome

Prenatal and Neonatal Disorders:

  • Abnormal ultrasound

  • Advanced maternal age

  • Birth defects

  • Elevated AFP levels

  • Exposure to teratogens

  • Recurrent pregnancy loss

  • Trisomy (ex. Down Syndrome)

  • Unexplained pregnancy loss

Fertility Concerns:

  • Male/female infertility

  • Recurrent pregnancy loss

  • Parental/sibling studies in families with a known chromosomal abnormality

Experienced staff

At the center, meticulous work, experienced staff and innovative approaches are united with a genuine commitment to providing you and your family with information that can be empowering.

Seasoned leadership and highly skilled researchers bring extensive experience to bear on each case:

  • The medical director is a board-certified geneticist and pediatrician, with more than 25 years of experience in genetic research and counseling.

  • Technical staff members are specially certified in cytogenetics by the American Society of Clinical Pathologists (ASCP).

A far-ranging resource

The center works with clients across the state and the region. Most clients are referred to the center, which works in conjunction with genetic counseling, pediatric, oncology and primary care practices. In addition, social service agencies other hospitals and specialty practices in fields such as neurology, psychiatry and fertility refer patient samples to this facility for testing.

In addition, the Parkview Genetics Center contributes to next-generation research projects conducted by universities and other institutions, and is part of a cancer research group sponsored by the National Cancer Institute, dedicated to developing better treatments for cancer.

For physicians: The latest testing techniques

The Parkview Genetics Center offers a large array of cytogenetic and FISH testing as diagnostic tools for physicians in a variety of fields.

Cytogenetics:

Cytogenetics is a branch of genetics that involves the study of normal and abnormal chromosomes  –  the physical structures that contain DNA within cells. Cytogenetics studies are essential to the diagnosis and treatment of many diseases, from Downs Syndrome to Leukemia.

FISH:

Fluorescence In situ Hybridization (FISH) is a method of examining chromosomes on the DNA level. It is used to look at small and very specific segments of the DNA strand to see if each is present or absent. FISH studies are done when a physician is looking for a very specific abnormality. These studies complement chromosome studies in providing valuable information to the physician.

The Parkview Genetics Center offers the following FISH tests:

  • AneuVysion – Identifies and enumerates critical chromosomes from amniotic fluid in high-risk pregnancies.

  • Angelman’s – Detects micro-deletions of chromosome 15 associated with Angelman syndrome.

  • BCR-ABL – Identifies and monitors the Philadelphia chromosome in patients with CML (chronic myelogenous leukemia), ALL (acute lymphoblastic leukemia), or AML (acute myelogenous leukemia).

  • CLL Panel – Detects deletions/duplications in chromosomes associated with CLL (chronic lymphocytic leukemia).

  • HER-2/neu –  Adjunct testing to aid in diagnosis and treatment of certain breast cancers.

  • Inverted 16 – Aids in the classification/evaluation/ monitoring of a certain AML.

  • Miller-Dieker Syndrome – Detects micro-deletions of chromosome 17 associated with Miller-Dieker syndrome.

  • Prader Willi Syndrome –Detects micro-deletions of chromosome 15 associated with Prader-Willi syndrome.

  • RARA – Used in the classification/evaluation/monitoring of a certain AML.

  • Shprintzen/DiGeorge – Detects micro-deletions of chromosome 22 associated with Shprintzen/DiGeorge syndrome.

  • Smith-Magenis  – Detects micro-deletions of chromosome 17 associated with Smith-Magenis syndrome.

  • Sotos Syndrome – Detects micro-deletions of chromosome 5 associated with Sotos syndrome.

  • SRY – Aids in the diagnosis of a deletion/duplication in the sex-determining region of the Y chromosome.

  • Subtelomere – Detects micro-deletions of the terminal portions of certain chromosomes.

  • Williams Syndrome – Detects micro-deletions of chromosome 7 associated with Williams syndrome.

Now offering chromosomal microarray analysis (CMA)

In 2011, the center added CMA, the very latest in chromosomal analysis. More sensitive than the traditional karyotype testing, this revolutionary technology can detect genetic abnormalities on all chromosomes in a single test. It is performed on blood samples.

CMA is increasingly being regarded as a first-tier test in diagnosing and addressing disorders. The American Academy of Pediatrics, the American College of Medical Genetics and other professional medical organizations now recommend CMA testing early, as it can reduce the time, frustration and medical expenses involved in identifying underlying genetic causes.

Primary care physicians are encouraged to order CMA, even for common symptoms. Physicians can order CMA using Array Comparative Genomic Hybridization (aCGH) for patients with any indication of genomic imbalance or chromosomal damage, including: dysmorphic features, unexplained mental retardation/developmental delay, autism spectrum disorder, seizure disorders, learning disabilities and/or multiple congenital anomalies.

 Some insurance carriers do cover the costs of CMA testing, depending on individual policy limitations. For help with pre-authorization, contact us at (260) 266-9250. Questions are welcome.

Visiting the center

The Parkview Genetics Center is located on the third floor of the Parkview Comprehensive Cancer Center on the Parkview Regional Medical Center Campus. Free valet parking is available at Entrance 4.

The center is open Monday through Saturday, 8 a.m. – 4:30 p.m.

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