Fluorescence In situ Hybridization (FISH) is a method of examining chromosomes on the DNA level. It is used to look at small and very specific segments of the DNA strand to see if each is present or absent. FISH studies are done when a physician is looking for a very specific abnormality. These studies complement chromosome studies in providing valuable information to the physician.
The Parkview Genetics Center offers the following FISH tests:
- AneuVysion – Identifies and enumerates critical chromosomes from amniotic fluid in high-risk pregnancies.
- Angelman’s – Detects micro-deletions of chromosome 15
associated with Angelman syndrome.
- BCR-ABL – Identifies and monitors the Philadelphia chromosome in patients with CML (chronic myelogenous leukemia), ALL (acute lymphoblastic leukemia), or AML (acute myelogenous leukemia).
- CLL Panel – Detects deletions/duplications in chromosomes associated with CLL (chronic lymphocytic leukemia).
- HER-2/neu – Adjunct testing to aid in diagnosis and
treatment of certain breast cancers.
- Inverted 16 – Aids in the classification/evaluation/ monitoring of a certain AML.
- Miller-Dieker Syndrome – Detects micro-deletions of
chromosome 17 associated with Miller-Dieker syndrome.
- Prader Willi Syndrome –Detects micro-deletions of
chromosome 15 associated with Prader-Willi syndrome.
- RARA – Used in the classification/evaluation/monitoring of
a certain AML.
- Shprintzen/DiGeorge – Detects micro-deletions of
chromosome 22 associated with Shprintzen/DiGeorge
- Smith-Magenis – Detects micro-deletions of chromosome
17 associated with Smith-Magenis syndrome.
- Sotos Syndrome – Detects micro-deletions of
chromosome 5 associated with Sotos syndrome.
- SRY – Aids in the diagnosis of a deletion/duplication in the
sex-determining region of the Y chromosome.
- Subtelomere – Detects micro-deletions of the terminal
portions of certain chromosomes.
- Williams Syndrome – Detects micro-deletions of
chromosome 7 associated with Williams syndrome.